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BioMARC of Colorado State University Awarded Subcontract to Assist in Ebola Vaccine Development and Manufacturing

Fort Collins, CO.  October 27, 2014 —  

Colorado State University’s Biopharmaceutical Manufacturing and Academic Resource Center (BioMARC) has been awarded $2 million by the U.S. Department of Defense (DoD) to aid in the development and manufacture of a vaccine to protect against infection by filoviruses, including the Ebola and Marburg viruses.

The $2 million subcontract was awarded by Battelle Memorial Institute, a research organization that serves the DoD Medical Countermeasure Systems Joint Vaccine Acquisition Program (MCS-JVAP). Among MCS-JVAP’s requirements is to develop a vaccine to protect soldiers from aerosolized exposure to filoviruses, which cause several types of hemorrhagic fever. BioMARC will make contributions toward furthering the development of a replicon vaccine platform containing a non-infectious Ebola antigen, which has been shown to protect nonhuman primates from an intramuscular and aerosol challenge with the Ebola virus.

To date, there are no licensed or Food and Drug Administration-approved human vaccines or therapeutics to protect against or treat filovirus infections. Diseases caused by filoviruses have high mortality rates; as many as 90 percent of those infected may die.

While the primary purpose of the Ebola vaccine would be to protect U.S. soldiers, it is possible that such a vaccine could be used for endemic outbreaks of filovirus infection. The current outbreak of the Ebola virus in West Africa has killed more than 3,400 people since March 2014, according to the World Health Organization.

“We welcome the opportunity to assist in a project that is of such great significance to protecting human health,” said Dennis Pierro, BioMARC’s director and a professor at Colorado State University. “BioMARC was created to help with such projects.”


The role of MCS is to provide U.S. military forces and the nation with safe, effective and innovative medical solutions to counter chemical, biological, radiological and nuclear threats. MCS facilitates the advanced development and acquisition of medical countermeasures and systems to enhance the nation’s biodefense response capability.


BioMARC is a nonprofit Contract Manufacturing Organization (CMO) owned and operated by CSU and part of the Infectious Disease Research Center (IDRC) on the foothills campus.  It was created to produce biopharmaceutical products for non-clinical, clinical, and commercial use under Biosafety Level 3 (BSL-3) and BSL-2 containment and Select Agent (SA) biosecurity conditions.  BioMARC has expertise in developing and optimizing product manufacturing processes and related tests for therapeutic, vaccines, and diagnostic products.  Recently, BioMARC’s production areas were inspected by the US-CDC for manufacturing of complex biologics including toxins. In addition to manufacturing and testing services, BioMARC offers product and process development services, which includes the creation of development programs focused on implementation of cGMP regulations and scalability issues.  

Please visit us at or contact Patrick Berner at, (970) 492-4353 for more information.

Dennis Pierro, PhD                                                            
(970) 491-8954                                                                   

Patrick Berner                                                         
Manager, Business Development
(970) 492-4353



Contact Information

Dennis Pierro, PhD                                                     
(970) 491-8954

Sandy Brown
Contract Supervisor
(970) 492-4385